Managed Access Programs

Managed Access
Programs UK
for Pre-Launch & Post-Trial Supply

Euro Biom is an MHRA WDA-licensed UK logistics partner for Managed Access Programs (MAPs), including compassionate use, expanded access, EAMS early access and post-trial supply for biotech and specialty pharma sponsors.

MHRA WDA Licence No. WDA(H) 59239Granted 17 March 2026
Discuss Your Programme How It Works

⚡ Same-day response to every enquiry  ·  Mon-Fri 09:00-18:00  ·  WhatsApp us

What is a Managed Access Program
Patient access
before market
authorisation.

A Managed Access Program is a pharmaceutical-sponsored programme that enables patients to access an investigational, unlicensed or pre-launch medicine ahead of full marketing authorisation. MAPs typically respond to serious or life-threatening conditions where no licensed alternative is suitable.

In the UK the framework includes compassionate use under Regulation 167 of the Human Medicines Regulations 2012, the MHRA Early Access to Medicines Scheme (EAMS) for promising pre-licensing products, post-trial access for clinical trial participants, and named patient supply within MAP umbrella programmes.

For pharma sponsors, MAPs deliver pre-launch evidence, ethical patient access ahead of authorisation, and a structured route to manage demand from clinicians and patient advocacy groups during the regulatory review window. The execution requires an MHRA-authorised logistics partner.

Compassionate Use EAMS Early Access Post-Trial Supply Named Patient under MAP
"A Managed Access Program is the bridge between clinical trial closure and market launch. The patients who depend on it cannot wait, and the sponsor cannot afford a logistics partner that does not understand MHRA expectations."
Programme Types
Four MAP Frameworks
We Support

The right MAP framework depends on the regulatory stage of the medicine, the patient population and the sponsor's strategic objective. We support all four.

Type 01
🩸
Compassionate Use Programme
Supply of an unlicensed medicine to identified patients with a serious unmet medical need under Regulation 167 of the Human Medicines Regulations 2012. Suitable for products in late-stage clinical development or recently approved in another jurisdiction but not yet UK-licensed. Patient-named, prescriber-led, sponsor-funded.
Type 02
EAMS Early Access
The UK Early Access to Medicines Scheme, run by the MHRA, allows pre-licensing access to medicines that have received a positive scientific opinion. Suitable for promising new therapies addressing serious unmet need where the sponsor wants structured pre-launch access for cohorts of patients across multiple sites.
Type 03
🧪
Post-Trial Access Programme
Continued supply of an investigational medicine to clinical trial participants after trial closure, until commercial launch or alternative access. An ethical commitment increasingly written into trial protocols and consent documents, requiring a logistics partner who understands trial-to-MAP transition handover.
Type 04
🩺
Named Patient Access under MAP
Single-patient access within a sponsor-led MAP umbrella programme. Combines the patient-level individuality of named patient supply with the sponsor governance, pricing structure and pharmacovigilance reporting of a formal Managed Access Program. Ideal for ultra-rare conditions with sporadic demand.
Why Pharma Sponsors Run MAPs
Pre-Launch Evidence,
Ethics, and Demand Management

A well-designed MAP delivers strategic, ethical and operational value during the pre-licensing or pre-launch window.

📊
Pre-Launch Real-World Evidence
MAP supply generates real-world data on dosing, tolerability and outcomes in routine clinical use, supporting payer dossier preparation, NICE submissions and post-launch HTA work.
💍
Ethical Patient Access
For serious unmet need indications, compassionate access ahead of authorisation is increasingly an ethical and reputational expectation from clinicians, regulators and patient advocacy groups.
🎯
Demand Management Pre-Launch
A structured MAP gives the sponsor a controlled framework for responding to clinician requests during the regulatory review window, avoiding ad-hoc unlicensed import pressure on local distributors.
The Euro Biom MAP Service

UK logistics, distribution
and patient-level documentation.

MAPs are operationally complex. Investigational product handling, patient-level traceability, sponsor reporting and MHRA liaison must all run in parallel. Our service is designed for sponsors who need a UK partner that already has the regulatory authorisation in place.

UK Receipt and GDP Storage

Receive investigational or pre-launch product from the sponsor or contract manufacturer at our GDP-audited UK warehouse. Cold chain handling for refrigerated and frozen formulations, full receipt documentation, and quarantine controls where required by the sponsor's quality system.

+2 to +8 cold chain  |  GDP-audited site

Patient-Named Distribution

Patient-level dispatch to UK hospitals, specialist centres and homecare providers, with full chain-of-custody from receipt through to clinical site. International shipment under our WDA export authorisation, with destination-country import liaison.

UK and 40+ international destinations

Patient-Level Documentation

Each dispatch is documented at patient level, supporting sponsor pharmacovigilance reporting, outcomes analysis and any obligations under the MAP protocol. Documentation is structured for easy reconciliation against sponsor systems and clinical site records.

Patient-level audit trail

Regulatory Liaison and Reporting

For EAMS, compassionate use and named patient programmes, we liaise with the MHRA on supply-related queries, maintain the wholesaler-side documentation expected for a Managed Access Program, and provide the sponsor with reporting needed for periodic regulatory updates.

MHRA liaison  |  Sponsor reporting
How It Works
From Programme Design
to Outcomes Documentation

A typical Managed Access Program runs over months or years. Our process is designed for the long-running operational rhythm sponsors need.

Step 01
01
Programme Design Support
Discuss programme type, indication, expected patient volume, country scope and timeline. Joint design of the logistics workflow, documentation requirements and regulatory touchpoints.
Step 02
02
Patient Registration and Site Set-Up
Set up clinical sites and patient registration workflows. Establish dispatch templates, sponsor reporting cadence and patient-level documentation standards before the first supply.
Step 03
03
Drug Supply and Distribution
Receive product, store under GDP, dispatch at patient or site level. Cold chain monitoring, full chain-of-custody documentation, customs clearance for international shipments.
Step 04
04
Outcomes and Programme Documentation
Periodic reporting to the sponsor on supply volumes, patient distribution, expiry and recall management. Full programme documentation for regulatory review, audit and post-launch transition.
Where MAP Demand Concentrates
Therapeutic Areas We Support

MAPs are most common in indications where unmet need is high and the patient population cannot wait for full licensing and reimbursement.

🩺
Rare Disease
Ultra-rare and orphan indications where the patient population is small, the unmet need is acute, and a sponsor-led MAP is the only realistic access route pre-launch.
🔬
Oncology
Pre-licensing access to targeted therapies, immunotherapies, CAR-T and novel cytotoxics for patients with limited or exhausted licensed treatment options.
🧑‍🬊
Paediatric
Compassionate use and EAMS programmes for paediatric indications, including paediatric oncology, neurology and metabolic conditions where adult-licensed therapies are extrapolated.
🧮
Ultra-Rare Metabolic
Inherited metabolic disorders, lysosomal storage diseases and genetic conditions requiring lifelong therapy, often with global patient registries and small national cohorts.
🧠
Neurology
Programmes for ALS, advanced MS, rare epilepsy syndromes and neurodegenerative conditions where licensed options are limited and post-trial access is ethically expected.
🧡
Cardiovascular Rare
Pulmonary arterial hypertension, hereditary amyloidosis, transthyretin disease and rare cardiomyopathies addressed through specialist centre MAPs.
🧹
Immunology and Inflammation
Pre-launch access to novel biologics for severe autoimmune, dermatologic and rheumatologic conditions, including post-trial bridging supply.
💊
Other Indications
MAP frameworks apply across all therapeutic categories. Submit your programme details for a logistics design proposal regardless of indication.

Ready to Discuss Your MAP?

Tell us the indication, programme type, expected volume and country scope. We respond the same working day with a logistics design proposal covering distribution, documentation and regulatory liaison. Confidentiality assured.

Frequently Asked Questions
Managed Access Programs, Explained

Common questions from biotech and specialty pharma sponsors planning a UK MAP.

What is a Managed Access Program?
A pharma-sponsored programme providing patients with access to an investigational or unlicensed medicine before full marketing authorisation. MAPs include compassionate use, expanded access, EAMS early access and post-trial supply, typically for serious unmet need where no licensed alternative is suitable.
What is the difference between compassionate use and early access?
Compassionate use is a regulatory pathway for unlicensed supply on a named patient basis. Early access, including UK EAMS, is a structured sponsor-led programme allowing groups of patients to access a promising medicine before licensing, typically backed by a positive MHRA scientific opinion.
What does Euro Biom do for a MAP?
We act as the UK MHRA-licensed logistics partner. Receipt of investigational or unlicensed product, GDP-compliant storage, patient-level or site-level distribution within the UK or for export, full chain-of-custody documentation, temperature monitoring, and MHRA regulatory liaison.
Can you support international Managed Access Programs?
Yes. Our WDA covers export, and we ship MAP product from the UK to GCC, Africa, Europe and beyond. We manage UK export documentation including Certificates of Pharmaceutical Product where required, and coordinate with sponsor regulatory teams on import requirements at the destination.
What documentation comes with each MAP supply?
Every supply includes a Certificate of Analysis, batch records, GDP transport and temperature monitoring documentation, patient-level or site-level dispatch records, and any export or import paperwork. Documentation supports sponsor pharmacovigilance, regulatory reporting and outcomes analysis.
How do I set up a MAP with Euro Biom?
Contact us with the indication, programme type, expected patient volume, country scope and timeline. We respond the same working day with a programme design proposal covering logistics, documentation, regulatory liaison and pricing. Confidentiality assured.